2020 Iowa State Cyclones Football Schedule
***All times to be announced***
| Date | Opponent |
| September 5 | vs. South Dakota |
| September 12 | at Iowa |
| September 19 | vs. UNLV |
| September 26 | vs. Texas Tech |
| October 3 | at Kansas |
| October 10 | at Oklahoma State |
| October 17 | vs. Oklahoma (Homecoming) |
| October 29 (Thursday) | vs. Kansas State |
| November 7 | at TCU |
| November 14 | vs. Baylor |
| November 21 | at Texas |
| November 28 | vs. West Virginia |
